Analysis of brain and genetic data

Modern experimental neuro-science has been revolutionarized by sophisticated measurement equipment, such as fMRI, MEG and others. Also, the advances in EEG measurement systems has accelerated the research on Brain Computer Interfaces. Thirdly, research tools in genetics have led to an explosion of DNA and expression data. These massive data sets require advanced data analysis tools. Machine learning methods (kernel methods, sparse dimension reduction methods, ICA, Bayesian approaches) provide the most promising approach to analyze these data.

We are engaged in collaboration with Human Genetics on the genetic origin of disorders. In the past, we have applied an advanced approximate inference method (the Cluster Variation Method) to construct haplotypes in complex pedigrees. The software is publicly available. Aladin is a software tool for performing efficient linkage analysis of a small number of distantly-related individuals. It estimates multipoint IBD probabilities and parametric LOD scores. We currently analyze data from genome-wide association studies using a Bayesian Gaussian process regression approach (with Prof. Han Brunner, and Prof. Barbara Franke).

We are engaged in collaboration with Human Genetics on the analysis of fMRI images and their genetic correlates in collaboration with Prof. Jan Buitelaar and Prof. Christian Beckmann.

Brain Computer Interface

Since 2009, we have started research on the design of an adaptive BCI system, based on the idea that subjects will be surprised when the BCI output differs from their expectation. This surprise is measurable as a so-called error potential. The detection of the error potential can be used to adapt the BCI device, using Bayesian inference.

Related Articles

Duane G.S., Wiegerinck W.A.J.J., Selten F., Shen M.L, Keenlyside N.
Supermodeling: synchronization of alternative dynamical models of a single objective process .
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Kappen H.J.
Learning quantum models from quantum or classical data.
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Attractor learning in synchronized chaotic systems in the presence of unresolved scales.
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Duane G.S., Wiegerinck W.A.J.J., Selten F., Shen M.L, Keenlyside N.
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Advanced in Nonlinear Geosciences, pp. 101-121, 2017

file type image Thijssen S.A., Kappen H.J.
Path integral control and state dependent feedback.
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